Compositions for immunizing against mycobacterium

Details Compositions for immunizing against mycobacterium Compositions for immunizing against mycobacterium

A - Human Necessities

61

K

A61K 39/04 (2006.01) C07K 14/35 (2006.01)

Patent

CA 2592756

A method for generating a T cell immune response in a host involving administering a vectored vaccine comprising a non-replicating or replication impaired viral vector expressing the translation product of a mycobacterial antigen 85A gene. Vectored vaccines and uses thereof are also provided. Also provided is a method of inducing a CD8 and a CD4 memory T cell response against an antigen using an adenovirus vector expressing an antigen or an immunogenic fragment thereof.

L'invention concerne une méthode permettant de générer une réponse immunitaire des lymphocytes T chez un hôte. Cette méthode consiste à administrer un vaccin vectorisé qui comprend un vecteur viral non répliquant ou à réplication altérée exprimant le produit de traduction d'un gène 85A de l'antigène mycobactérien. L'invention concerne également des vaccins vectorisés et leurs utilisations. L'invention concerne enfin une méthode permettant d'induire une réponse des lymphocytes T mémoire CD8 et CD4 contre un antigène au moyen d'un vecteur exprimant un antigène ou un fragment immunogène de ce dernier.

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