Recombinant retroviruses delivering vector constructs to...

Details Recombinant retroviruses delivering vector constructs to... Recombinant retroviruses delivering vector constructs to...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A01K 67/027 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) C07K 14/155 (2006.01) C07K 14/73 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/48 (2006.01) C12N 15/867 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2066053

Recombinant retroviruses carrying a vector con- struct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune dis- eases are disclosed. More specifically, the recombi- nant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a func- tion of a pathogenic agent, such as a virus; and (c) in- hibiting the interaction of an agent with a host cell re- ceptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a rec- ombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.

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