Use of epothilones in the treatment of brain diseases...

A - Human Necessities – 61 – K

Patent

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Details

IPC codes

A61K 31/428 (2006.01) A61K 31/423 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 493/04 (2006.01)

Type

Patent

Patent number

CA 2477403

Description

This invention provides the use of an Epothilone, which shows an average distribution coefficient between plasma and brain of 0.3 to 1.5 in the mouse intravenous bolus injection assay, for the preparation of a medicament for the treatment of a brain disease associated with proliferative processes.

Cette invention concerne l'emploi d'un épothilone, qui présente un coefficient de répartition entre le plasma et le cerveau compris entre 0,3 e 1,5 dans le cadre d'un essai d'injection d'un bol intraveineux chez la souris. Cet épothilone intervient dans la préparation d'un médicament pour le traitement de maladies du cerveau à caractère prolifératif.

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