Monocyclic and bicyclic himbacine derivatives useful as...

Details Monocyclic and bicyclic himbacine derivatives useful as... Monocyclic and bicyclic himbacine derivatives useful as...

C - Chemistry, Metallurgy

07

D

C07D 213/24 (2006.01) A61K 31/44 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2647933

Monocyclic and bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt or solvate of said compound wherein represents an optional double bond and wherein Gn, Jn, R3, R8, R9, R10, R11, R32, R33, B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed.

L'invention concerne des dérivés d'himbacine monocycliques et bicycliques de formule: (formule I) ou bien un sel ou un solvate pharmaceutiquement acceptable de ce composé, formule dans laquelle === représente une double liaison optionnelle et Gn, Jn, R3, R8, R9, R10, R11, R32, R33, B et Het sont définis ci-après. L'invention porte également sur des compositions pharmaceutiques les contenant et sur une méthode d'administration desdits composés pour traiter des maladies associées à la thrombose, l'athérosclérose, la resténose, l'hypertension, l'angine de poitrine, l'arythmie et l'insuffisance cardiaque, ainsi que le cancer. L'invention concerne aussi une polythérapie avec d'autres agents.

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