Phenanthridine-n-oxides

Details Phenanthridine-n-oxides Phenanthridine-n-oxides

C - Chemistry, Metallurgy

07

D

C07D 221/12 (2006.01) A61K 31/473 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2396026

N-oxides of the compounds of formula (I) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C- cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine- substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C- alkylenedioxy group, R6 is an R7- and R8-substituted phenyl radical, they are active bronchial therapeutics.

L'invention concerne les N-oxydes des composés représentés par la formule (I), dans laquelle R1 représente un groupe hydroxy, 1-4C-alcoxy, 3-7C-cycloalcoxy, 3-7C-cycloalkylméthoxy ou un groupe 1-4C-alkoxy entièrement ou principalement substitué par fluorine, R2 représente un groupe hydroxy, 1-4C-alcoxy, 3-7C-cycloalcoxy, 3-7C-cycloalkylméthoxy ou un groupe 1-4C-alkoxy entièrement ou principalement substitué par fluorine, ou dans laquelle R1 et R2 représentent ensemble un groupe 1-2C-alkylènedioxy, R6 représente un radical phényle substitué par R7 et R8. Les N-oxydes sont des substances thérapeutiques bronchiques actives.

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