Stabilization of solid thyroid drug formulations

Details Stabilization of solid thyroid drug formulations Stabilization of solid thyroid drug formulations

A - Human Necessities

61

K

A61K 47/44 (2006.01) A61K 9/10 (2006.01) A61K 9/18 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/198 (2006.01) A61P 5/14 (2006.01)

Patent

CA 2641570

The invention provides a drug dosage form prepared by compression techniques comprising: a substantially non-volatile, pharmaceutically acceptable oil, and a thyroid drug treated with the substantially non-volatile, pharmaceutically acceptable oil to substantially waterproof the thyroid drug; the drug dosage form prepared by: (a) dispersing the thyroid drug in the substantially non--volatile, pharmaceutically acceptable oil; and (b) compacting the thyroid drug into dosage forms using compression pressures of up to 5,000 psi/g. The dosage form may be used for treating a patient in need of thyroid replacement therapy.

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