A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/137 (2006.01) A61K 31/69 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2660939
Synergistic combinations of a squalene epoxidase inhibitor and a leucyl-tRNA synthetase inhibitor are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin or nail plays a role, such as atopic dermatitis, acne vulgaris, seborrhoeic dermatitis, rosacea or onychomycosis, and in situations of fungal resistance.
La présente invention concerne des combinaisons synergiques d'un inhibiteur de la squalène époxydase et d'un inhibiteur de la synthétase de la leucyl-ARNt, qui sont utiles en particulier pour le traitement de maladies s'accompagnant d'une infection fongique réelle ou suspectée, pour l'immunomodulation ou l'immunosuppression dans des affections impliquant une colonisation fongique ou fongique suspectée de la peau ou des ongles, par exemple, comme la dermatite atopique, l'acné vulgaire, la dermatite séborrhéique, l'acné rosacée ou l'onychomycose, et dans des cas de résistance fongique.
Fetherstonhaugh & Co.
Novartis Ag
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