Ctla-4 protein variants

Details Ctla-4 protein variants Ctla-4 protein variants

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01)

Patent

CA 2666778

Protein variants of CTLA-4, which show increased activity compared to wild-type in a cell assay and which exhibit increased stability. Such variants are useful for treatment of disorders whereby attenuation of the T cell response would be beneficial.

L'invention concerne des variants protéiques de CTLA-4, qui présentent une activité accrue comparée au type sauvage dans un dosage de cellules et qui montrent une stabilité accrue. De tels variants sont utiles pour le traitement de troubles où l'atténuation de la réponse des lymphocytes T serait utile.

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