Biochemical methods for detecting cervical dysplasia and cancer

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 39/395 (2006.01) C12Q 1/00 (2006.01) G01N 33/544 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2309330

Primary screening for cervical dysplasia is effected by measuringa biochemical marker of apoptosis and/or angiogenesis in each of a population of cells derived from convenient, superficial swabbing, sponging, scraping or lavage of superficial eptithelial cells from the cervix, wherein the marker indicates the presence of cervical dysplasia in the sample, and scoring the results of the measuring step for cervical displasia (i.e. ascertaining whether or not the marker is present) in the patient in the absence of any cythological examination.

Un dépistage primaire de dysplasie du col est effectué par la mesure d'un marqueur biochimique d'apoptose et/ou d'angiogénèse dans chaque population de cellules dérivées d'un écouvillonnage, d'un prélèvement par absorption ou raclage approprié en surface ou par lavage de cellules épithéliales superficielles sur le col. Le marqueur indique la présence d'une dysplasie du col dans l'échantillon. Ensuite, on évalue les résultats de l'étape de mesure d'une dysplasie du col (c'est-à-dire l'évaluation de la présence ou non du marqueur) chez le patient, en l'absence de tout examen cytologique.

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