C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/04 (2006.01) C12P 7/02 (2006.01) C12P 7/22 (2006.01) C12P 7/26 (2006.01) C12P 17/00 (2006.01) C12P 17/04 (2006.01)
Patent
CA 2747058
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.
La présente invention porte sur des mutants de phényléthanol déshydrogénase d'un nouveau type, sur un procédé permettant de les fabriquer, sur des séquences d'acides nucléiques codant pour ceux-ci, des cassettes d'expression, des vecteurs et des microorganismes recombinants, lesquels contiennent ces séquences; sur un procédé de synthèse biocatalytique d'alcools substitués, optiquement actifs, par utilisation de ces mutants; et en particulier sur un procédé de fabrication d'alcool de duloxétine ou de duloxétine, comportant une étape de synthèse biocatalytique catalysée par ces mutants.
Hoeffken Wolfgang
Schneider Nina
Basf Se
Robic
LandOfFree
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