C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/43 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) C07C 211/60 (2006.01) C07C 233/80 (2006.01) C07C 275/40 (2006.01) C07C 311/08 (2006.01) C07D 209/14 (2006.01) C07D 233/32 (2006.01) C07D 233/36 (2006.01) C07D 295/155 (2006.01) C07D 307/81 (2006.01) C07D 333/58 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2151377
Compound having general formula (I) wherein one of X and Y is CH2 and the other one is CH2, O or S; R1 is an aliphatic hydrocarbon group, arylalkyl, aryl, a sulphonyl group, a carbonate group or R11R12NCO- where R11 and R12 are selected form hydrogen and a hydrocarbon group; R2 is hydrogen or a hydrocarbon group; R3-R5 an independently selected from hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, alkylsulphonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylalkyl or nitro; R6 and R7 are each hydrogen or lower alkyl or they are linked together to constitute a carbocyclic ring; R8 and R9 are independently hydrogen, a hydrocarbon group or a group 1a wherein R13 is hydrogen, or a hydrocarbon group, W is O or S, and r is 2-6; R8 and R9 are linked together thereby forming alkylene group; have effect at central 5-HT1A receptors and are useful in the treatment of psychosis, anxiety disorders, depression, impulse control disorders, alcohol abuse, aggression, ischaemic diseases, side effects induced by conventional antipsychotic agents or cardiovascular disorders.
H. Lundbeck A/s
Robic
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