Nervonic acid derivatives, their preparation and use

Details Nervonic acid derivatives, their preparation and use Nervonic acid derivatives, their preparation and use

C - Chemistry, Metallurgy

07

C

C07C 69/533 (2006.01) A61K 31/231 (2006.01) C07C 67/08 (2006.01) C07C 67/14 (2006.01) C07C 69/587 (2006.01)

Patent

CA 2391953

The present invention relates to a nervonic acid derivatives of formula (I) wherein R is hydrogen (H) or a residue of a carboxylic acid; or a salt of the compound where R is H; or a bioprecursor, prodrug or hydrate thereof. Those compounds wherein R is other than H have pharmacological activity, in particular anti-inflammatory and immunomodulatory effects. Those compounds wherein R is H can be used to prepare the pharmacologically active derivatives.

L'invention concerne des dérivés d'acide nervonique représentés par la formule (I) dans laquelle R est hydrogène (H) ou un reste d'acide carboxylique; ou un sel du composé dans lequel R est hydrogène; ou un bioprécurseur, un promédicament ou un hydrate de ce dernier. Les composés dans lesquels R est autre qu'hydrogène, présentent une activité pharmacologique, en particulier, des effets anti-inflammatoires et immunomodulateurs. Les composés dans lesquels R est hydrogène, peuvent être utiliser pour préparer les dérivés pharmacologiquement actifs.

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