Human pancreas and pancreatic cancer associated gene...

Details Human pancreas and pancreatic cancer associated gene... Human pancreas and pancreatic cancer associated gene...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2366195

This invention relates to newly identified pancreas or pancreatic cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "pancreatic cancer antigens", and to the complete gene sequences associated therewith and to the expression products thereof, as well as the use of such pancreatic cancer antigens for detection, prevention and treatment of disorders of the pancreas, particularly the presence of pancreatic cancer. This invention relates to the pancreatic cancer antigens as well as vectors, host cells, antibodies directed to pancreatic cancer antigens and recombinant and synthetic methods for producing the same. Also provided are diagnostic methods for diagnosing and treating, preventing and/or prognosing disorders related to the pancreas, including pancreatic cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of pancreatic cancer antigens of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and/or function of the polypeptides of the present invention.

L'invention porte sur des polynucléotides et les polypeptides codés par eux nouvellement identifiés connus sous l'appellation collective d'"antigènes du cancer du pancréas", sur les séquences complètes de gènes leur étant associées, sur leurs produits d'expression, ainsi que sur l'utilisation desdits "antigènes du cancer du pancréas" pour la détection, la prévention et le traitement d'affections du pancréas dont en particulier le cancer du pancréas. L'invention porte sur les antigènes du cancer du pancréas ainsi que sur des vecteurs, des cellules hôtes, et des anticorps des antigènes du pancréas, et sur des procédés de recombinaison et de synthèse permettant de les produire. L'invention porte également sur des méthodes de diagnostic permettant de diagnostiquer, traiter, prévenir et/ou pronostiquer les affections du pancréas dont le cancer du pancréas, et sur des procédés thérapeutiques permettant de les traiter. L'invention porte en outre sur des procédés de criblage permettant d'identifier les agonistes et antagonistes des antigènes du cancer du pancréas de l'invention, et sur des procédés et/ou compositions inhibant la production et/ou la fonction des polypeptides de l'invention.

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