Novel indole derivatives

Details Novel indole derivatives Novel indole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/496 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 209/08 (2006.01)

Patent

CA 2395606

The invention provides compounds of formula (I) wherein X represents O or S; n is 2, 3, 4, 5, 6, 7, 8, 9 or 10; m is 2 or 3; Y represents N, C or CH; and the dotted line represents an optional bond; R1, R1', R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined in the description. The compounds are ligands of the 5-HT1a-receptor.

La présente invention concerne des composés représentés pr la formule (I). Dans cette formule, X est O ou S. "n" est un entier de 2 à 10. "m" vaut 2 ou 3. Y est N, C ou CH. Le pointillé est une liaison facultative. R?1¿, R?1'¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?11¿ et R?12¿ sont tels que définis dans la description. Ces composés sont des ligands du récepteur 5-HT¿1a?.

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