Macrocyclic inhibitors of matrix metalloproteinases and...

Details Macrocyclic inhibitors of matrix metalloproteinases and... Macrocyclic inhibitors of matrix metalloproteinases and...

C - Chemistry, Metallurgy

07

D

C07D 267/00 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) C07D 225/06 (2006.01) C07D 245/02 (2006.01) C07D 245/06 (2006.01) C07D 255/02 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 487/08 (2006.01) C07K 5/078 (2006.01)

Patent

CA 2277121

Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.

Cette invention concerne des composés macrocycliques qui correspondent à la formule (I). Ces composés consistent en de puissants inhibiteurs de métalloprotéinase matricielle, et peuvent être utilisés dans le traitement de maladies où la métalloprotéinase matricielle joue un rôle. Cette invention concerne également des compositions inhibant la métalloprotéinase matricielle, ainsi qu'un procédé d'inhibition de métalloprotéinase matricielle chez un mammifère.

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