Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

A - Human Necessities

61

K

A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/5383 (2006.01) A61K 31/542 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) A61P 35/00 (2006.01) C07D 498/04 (2006.01) C07D 515/04 (2006.01)

Patent

CA 2533435

The present invention relates to bicyclic tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente à des composés bicycliques de tétrahydropyridine utiles pour le traitement de maladies proliférantes cellulaires, pour le traitement de troubles associés à l'activité de la kinésine KSP, et pour l'inhibition de la kinésine KSP. L'invention a également trait à des compositions comportant de tels composés, et à leurs procédés d'utilisation pour le traitement du cancer chez des mammifères.

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