Treatment of ocular hypertension and glaucoma

Details Treatment of ocular hypertension and glaucoma Treatment of ocular hypertension and glaucoma

A - Human Necessities

61

K

A61K 31/5575 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2454422

The instant invention discloses a method for treatment of ocular hypertension and glaucoma, which comprises administrating topically to the eyes of a mammalian subject in need of such treatment more than 5 micrograms and less than 50 micrograms per eye per administration of 15-keto-prostaglandin compound having a ring structure at the end of the omega chain. The treatment of the present invention causes substantially no or reduced ophthalmic irritating side effect even in such a high dose.

Cette invention se rapporte à un procédé servant à traiter l'hypertension oculaire et les glaucomes et qui consiste à administrer en mode topique dans les yeux d'un sujet mammifère nécessitant un tel traitement plus de 5 µg et moins de 50 µg par oeil par administration d'un composé de 15-céto-prostaglandine comportant une structure cyclique à l'extrémité de la chaîne .omega.. Le traitement faisant l'objet de cette invention ne produit pour ainsi dire pas d'effets secondaires irritants l'oeil ou en produit à un niveau réduit, même à une telle dose élevée.

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