Treatment of neoplasms with viruses

Details Treatment of neoplasms with viruses Treatment of neoplasms with viruses

A - Human Necessities

61

K

A61K 39/245 (2006.01) A61K 35/76 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/15 (2006.01) A61K 39/155 (2006.01) A61P 35/00 (2006.01) C07K 16/24 (2006.01) C12N 7/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2370187

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

L'invention concerne des virus qui sont capables de se répliquer et donc de tuer des cellules néoplastiques présentant une déficience de la réponse antivirale médiée par interférons, et leur utilisation dans le traitement de maladies néoplastiques, dont le cancer et les grosses tumeurs. Selon cet aspect, les virus d'ARN et d'ADN sont utiles. Cette invention concerne également des méthodes de sélection, de conception, de purification et d'utilisation de ces virus en thérapie du cancer.

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