Compositions and methods for delivery of genetic material

Details Compositions and methods for delivery of genetic material Compositions and methods for delivery of genetic material

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 39/245 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2306733

A soluble ionic complex is formed by an aqueous mixture of a benzylammonium group-containing surfactant and a polynucleic acid sequence. When the mixture forms a vesicular complex, the sequence is packaged therein. This composition is useful in pharmaceutical compositions and in methods of delivering the polynucleic acid sequence (which preferably encodes a protein or peptide) to a cell for expression. Such methods are useful in therapy, as vaccines and as gene therapy agents.

L'invention concerne un complexe ionique soluble constitué d'un mélange aqueux d'un tensioactif renfermant un groupe de benzylammonium et d'une séquence d'acide polynucléique. Lorsque ce mélange forme un complexe vésiculaire, ladite séquence est encapsulée à l'intérieur de ce dernier. Cette composition est utile dans des compositions pharmaceutiques ainsi que pour des procédés destinés à apporter ladite séquence d'acide polynucléique (qui de préférence code pour une protéine ou un peptide) à une cellule, afin de diriger l'expression d'une protéine. Ces procédés peuvent notamment être suivis dans un traitement prophylaxique, ou être utilisés en tant que vaccins ou agents de thérapie génique.

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