Multibinding agents that modulate nmda receptors

Details Multibinding agents that modulate nmda receptors Multibinding agents that modulate nmda receptors

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 51/00 (2006.01) C07B 61/00 (2006.01) C07C 215/60 (2006.01) C07C 217/08 (2006.01) C07C 323/62 (2006.01) C07D 211/42 (2006.01) C07D 211/56 (2006.01) C07D 213/74 (2006.01) C07D 213/80 (2006.01) C07D 263/32 (2006.01) C07D 263/34 (2006.01) C07D 265/32 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 277/34 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14

Patent

CA 2319175

Disclosed are novel multi-binding compounds (agents) which bind to NMDA receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors, thereby modulating the biological processes and/or functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multibinding compound. The linker is selected such that the multibinding compound so constructed demonstrates increased modulation of the biological processes mediated by the NMDA receptor.

L'invention concerne des nouveaux composés (agents) de liaison multiple, lesquels se lient aux récepteurs de N-méthyl-D-aspartate (NMDA). Les composés de l'invention comprennent plusieurs ligands, chacun pouvant se lier à de tels récepteurs, modulant ainsi les processus et/ou fonctions biologiques de ceux-ci. Chaque ligand est attaché de manière covalente à un (des) segment(s) de liaison, lesquels peuvent être semblables ou différents, afin de constituer le composé de liaison multiple. On a choisi ce segment de liaison de manière que le composé de liaison multiple ainsi construit démontre une propriété accrue de modulation des procédés biologiques induits par le récepteur de NMDA.

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