Compositions containing hydrolytically unstable compounds

Details Compositions containing hydrolytically unstable compounds Compositions containing hydrolytically unstable compounds

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 31/4174 (2006.01)

Patent

CA 2425594

The present invention relates to a new stable oral pharmaceutical formulation comprising: a) a nucleus formed by a core; b) a first layer that comprises a polymer coating sealing the core and optionally one or more hydrophobic excipients; and c) a second layer coating the first layer, wherein said second layer comprises one or more labile pharmaceutically active compounds in one or more acceptable hydrophobic excipients.

La présente invention traite d'une nouvelle préparation pharmaceutique orale stable comportant : a) un corps formé par un noyau ; b) une première couche comprenant un revêtement polymère recouvrant hermétiquement le noyau, et éventuellement un ou plusieurs excipients hydrophobes ; et c) une seconde couche recouvrant la première couche, et comprenant un ou plusieurs composés pharmaceutiquement actifs labiles dans un ou plusieurs excipients hydrophobes acceptables.

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