C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/4164 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/4439 (2006.01) C07C 229/46 (2006.01) C07C 237/12 (2006.01) C07C 255/46 (2006.01) C07C 327/42 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 233/02 (2006.01) C07D 233/14 (2006.01) C07D 241/04 (2006.01) C07D 257/04 (2006.01) C07D 263/04 (2006.01) C07D 263/06 (2006.01) C07D 277/04 (2006.01) C07D 277/06 (2006.01) C07D 279/12 (2006.01) C07D 307/24 (2006.01) C07D 4
Patent
CA 2390231
The present invention provides the inhibitors of dipeptidyl peptidase IV based upon or including proline or similar moieties. The inhibitors are useful for treating various disorders, including those of the central nervous system and the prostate. Many of the inhibitors can be reversible, and can cross the blood-brain barrier. Methods of making and using the inhibitors and treatment methods also are provided.
Cette invention concerne des inhibiteurs de la dipeptidyl peptidase IV à base de proline ou de fractions similaires, ou contenant de la proline ou des fractions similaires. Ces inhibiteurs conviennent pour le traitement de troubles divers, dont ceux affectant le système nerveux central et la prostate. Bon nombre de ces inhibiteurs sont réversibles et peuvent traverser la barrière hémato-encéphalique. L'invention concerne également des méthodes de fabrication et d'utilisation des ces inhibiteurs ainsi que des méthodes de traitement.
Jackson Paul
Steiner Joseph
Guilford Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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