Oral vaccines for fish

Details Oral vaccines for fish Oral vaccines for fish

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 39/12 (2006.01) A61K 39/385 (2006.01) C12N 15/82 (2006.01)

Type

Patent

Patent number

CA 2595913

Description

The invention relates to the development, composition and production of mucosal (oral) vaccines for fish. More specifically, the invention relates to protein complexes for the delivery of antigens to and across mucosal surfaces of fish for the induction of an immune response, and to the production of said complexes in a host cell, preferably plants. Provided is the use of a protein complex comprising an antigen of interest fused to the B-subunit of Vibrio cholerae cholera toxin (CT-B), or Escherichia coli heat-labile enterotoxin (LT- B) for the manufacture of an oral fish vaccine. Also provided is fish feed comprising a protein complex of the invention

L'invention concerne l'élaboration, la composition et la production de vaccins mucosiques (oraux) pour poissons. Plus spécifiquement, l'invention concerne des complexes protéiques servant à libérer des antigènes sur les surfaces des muqueuses et dans les muqueuses des poissons pour provoquer une réponse immunitaire; l'invention concernant également la production desdits complexes dans une cellule hôte, de préférence des plantes. Par ailleurs, l'invention concerne l'utilisation d'un complexe protéique contenant un antigène recherché fusionné sur la sous-unité B de la toxine du choléra (CT-B) de Vibrio cholerae, ou l'entérotoxine thermolabile (LT-B) d'Escherichia coli, dans la mise au point d'un vaccin oral pour poissons. L'invention concerne en outre un aliment pour poisson qui contient un complexe protéique de l'invention.

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