A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7105 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C12N 5/02 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2635718
The present invention provides for a method of using CDC2L1, CSNK1A1, GYK, NEK1, PLK1, PRKAR1A, PRKRA, TTBK2 or TTK hedgehog kinase antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or overexpression of hedgehog, including cancer, cell proliferative disorders, and angiogenesis, neurological disorders, as well as other conditions affected by hedgehog signaling such as hair growth, neural stem cell differentiation, chondrogenesis and osteogenesis, lung surfactant production, formation of lamellated bodies in lung cells.
Procédé d'utilisation d'antagonistes de kinase hedgehog CDC2L1, CSNK1A1, GYK, NEK1, PLK1, PRKAR1A, PRKRA, TTBK2 ou TTK permettant d'inhiber la signalisation hedgehog, et par ailleurs de traiter et de diagnostiquer les troubles liés à la signalisation hedgehog ou à la surexpression hedgehog, y compris le cancer, les troubles liés à la prolifération cellulaire, l'angiogenèse, les troubles neurologiques, ainsi que d'autres états affectés par la signalisation hedgehog comme la pousse des cheveux, la différenciation des cellules souches neuronales, la chondrogenèse et l'ostéogenèse, et enfin la formation de corps lamellaires dans les cellules pulmonaires.
de Sauvage Frederic J.
Evangelista Marie
Curis Inc.
Genentech Inc.
Marks & Clerk
LandOfFree
Methods of using hedgehog kinase antagonists to inhibit... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of using hedgehog kinase antagonists to inhibit..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of using hedgehog kinase antagonists to inhibit... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1827383