C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/34 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) C07D 233/54 (2006.01) C07D 233/61 (2006.01) C07D 277/28 (2006.01) C07D 277/48 (2006.01) C07D 307/52 (2006.01)
Patent
CA 2322493
Nitrate salt compositions with anti-ulcer medicines having formula (A) and (B) wherein the (A) class compounds: R = H, OCH3, OCHF2; R1 = CH3, OCH3; R2 = H, CH3; R3 = CH3, CH2-CF3, (CH2)3-OCH3; wherein the (B) class compounds: RI3, RI4 equal to or different from each other, are respectively free valence hydrogen, (1), -CH2-N(CH3)2; Y = S, N-RI6, CRI7RI8; X = O, S, N-RI1; RI2 = H, CH3; n = 0, 1; Z = N-CN, N-SO2NH2, CH-NO2 or formula (VIIA) RI5 = H, -NH-CH3, NH2; RI6, RI7, RI8, RI1, equal to or different from each other, are hydrogen, free valence. The invention also comprises the methods for the preparation of above salts.
L'invention concerne des compositions à base de nitrates, utilisées dans des médicaments anti-ulcéreux et correspondant à la formule suivante: (A) et (B) Dans les composés de classe (A): R=H, OCH¿3?, OCHF¿2?; R¿1?=CH¿3?, OCH¿3?; R¿2?=H, CH¿3?; R¿3?=CH¿3?, CH¿2?-CF¿3?, (CH¿2?)¿3?-OCH¿3?; Dans les composés de classe (A): R?I¿¿3?, R?I¿¿4? sont identiques ou différents et sont respectivement valence libre, hydrogène, (1), -CH¿2?-N(CH¿3?)¿2?; Y=S, N-R?I¿¿6?, CR?I¿¿7?R?I¿¿8?,; X=O, S, N-R?I¿¿1?; R?I¿¿2?=H, CH¿3?; n=0, 1; Z=N-CN, N-SO¿2?NH¿2?, CH-NO¿2? ou (VII¿A?) R?I¿¿5?=H, -NH-CH¿3?, NH¿2?; R?I¿¿6?, R?I¿¿7?, R?I¿¿8?, R?I¿¿1?, identiques ou différents, sont hydrogène valence libre. L'invention concerne également des procédés de préparations de ces sels.
Gowling Lafleur Henderson Llp
Nicox S.a.
LandOfFree
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