Method and system for determining whether a drug will be...

G - Physics – 01 – N

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G01N 27/00 (2006.01) H01J 49/26 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2647871

A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug.

L'invention concerne un procédé permettant de déterminer si un patient atteint d'une maladie ou d'un trouble réagira à un médicament utilisé pour traiter la maladie ou le trouble, comprenant l'obtention d'un spectre de test fourni par un spectromètre de masse à partir d'un sérum prélevé chez le patient. Le spectre de test peut être traité pour déterminer une relation avec un groupe de spectres marqués par classes obtenus à partir de sérums respectifs d'autres patients ayant la même maladie ou le même trouble à un stade clinique similaire et connus pour avoir réagi ou ne pas avoir réagi au médicament. Sur la base de la relation du spectre de test par rapport au groupe de spectres marqués par classes, on peut déterminer si le patient réagira au médicament.

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