A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2264835
The present invention relates to methods and compositions for targeting nucleic acid sequences, more specifically double stranded nucleic acid sequences. The compositions comprise oligonucleotides in the form of padlock probes. The padlock probes have two free nucleic acid end parts which are at least partially complementary to and capable of hybridizing with two at least substantially neighboring respective regions of a target nucleic acid sequence. Furthermore, the invention relates to use of said compositions as medicaments for treating genetic disorders.
L'invention porte sur des procédés et des compositions pour cibler des séquences d'acide nucléique, en particulier des séquences d'acide nucléique à double brin. Ces compositions contiennent des oligonucléotides sous la forme de sondes cadenas. Ces sondes cadenas ont deux parties finales d'acide nucléique libres qui sont au moins partiellement complémentaires de deux régions respectives au moins sensiblement voisines d'une séquence d'acide nucléique cible, et qui sont capables de s'hybrider avec ces régions. L'invention concerne en outre l'utilisation desdites compositions comme médicaments pour traiter des affections génétiques.
Landegren Ulf
Smart & Biggar
LandOfFree
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