C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2682016
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as inhibitors of human stearoyl-CoA desaturase (SCD). The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention ofmedical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependentdiabetes mellitus, hypertension, metabolic syndrome, neurological diseases, immunedisorders, cancer and various skin diseases.
La présente invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, qui sont utiles en tant qu'inhibiteurs de la stéaroyl-CoA désaturase humaine (SCD). L'invention concerne, en outre, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés pour traiter ou prévenir les pathologies dans lesquelles la modulation de l'activité SCD est bénéfique, telles que les maladies cardiovasculaires, l'obésité, le diabète sucré non insulinodépendant, l'hypertension, le syndrome métabolique, les maladies neurologiques, les maladies immunes, le cancer et diverses maladies de peau.
Bergner Magnus
Brandt Peter
Bremberg Ulf
Hammer Kristin
Linden Auri
Inovacia Ab
Smart & Biggar
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