Bone marrow suppressing agents

Details Bone marrow suppressing agents Bone marrow suppressing agents

A - Human Necessities

61

K

167/101

A61K 51/04 (2006.01) A61N 5/10 (2006.01)

Patent

CA 2003326

The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from Samarium-153, Gadolinium-159, Holmium-166 and Yttrium-90 and at least one macrocyclic aminophosphonic acid ligand containing the 1,4,7,10-tetraazacyclododecane moiety, or a physiologically acceptable salt thereof. Suitable compositions for use in this method are also provided.

L'invention porte sur une méthode visant à éliminer la moelle osseuse par administration à un mammifère d'une composition, cette composition comprenant au moins un radionucléide éliminant la moelle osseuse choisi parmi les suivants : samarium 153, gadolinium 159, holmium 166 et yttrium 90 et au moins un ligand de l'acide aminophosphonique macrocyclique comprenant la variété 1,4,7,10 - tétra-azacyclododécane, ou encore un sel de ce genre aux caractéristiques physiologiques acceptables. On dévoile également des compositions adéquates pour l'emploi de la méthode.

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