Substituted .beta.-alanine derivatives as cell adhesion...

Details Substituted .beta.-alanine derivatives as cell adhesion... Substituted .beta.-alanine derivatives as cell adhesion...

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 207/48 (2006.01) C07D 211/34 (2006.01) C07D 211/60 (2006.01) C07D 211/96 (2006.01) C07D 217/26 (2006.01) C07D 241/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2309341

.beta.-Alanine derivatives of formula (I) are antagonists of VLA-4 and/or .alpha.4.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

Ces dérivés d'alanine-.beta. correspondant à la formule I sont des antagonistes de l'antigène très tardif 4 (VLA-4) et/ou .alpha.4.beta.7 et, en tant que tels, se révèlent efficaces s'agissant d'inhiber ou d'empêcher une adhésion cellulaire ainsi que d'agir sur des états pathologiques liés à l'adhésion cellulaire. Ces composés, qui peuvent se présenter sous l'aspect de compositions pharmaceutiques, se prêtent du mieux au traitement de l'asthme, d'allergies, d'états inflammatoires, de la sclérose en plaque ainsi qu'à celui d'autres affections de caractère inflammatoire et auto-immun.

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