Mdr resistance treatment

Details Mdr resistance treatment Mdr resistance treatment

C - Chemistry, Metallurgy

07

D

C07D 241/46 (2006.01) A61K 31/495 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2144783

The invention concerns the new use of riminophenazines in the treatment of a patient who has built up, or could build up, resistance to a therapeutically active substance, such as a patient requiring treatment for cancer. The riminophenazine conveniently may be of the general formula (I). Image (I) R1 is a hydrogen atom, a halogen atom or an alkyl, aLkoxy or fluoroalkyl radical, R2 is a hydrogen or halogen atom, R3 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, cycloalkylalkyl, or is a substituted or unsubstituted heterocyclic or heterocyclic-alkyl radical, R4 is a hydrogen or halogen atom or an alkyl, alkoxy or fluoroalkyl radical, and n is 1, 2 or 3. The invention also provides novel riminophenazines of general formula (I), their preparation, and compositions containing them.

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