C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 209/74 (2006.01) C07C 213/08 (2006.01) C07F 9/165 (2006.01)
Patent
CA 2628098
The present invention relates to processes for the preparation of (.omega.- aminoalkylainino)alkyl halides, their conversion to S-.omega.-(.omega.- aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (.omega.- aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (.omega.-aminoalkylamino)ethyl alcohol to amifostine.
La présente invention concerne des procédés de fabrication d~halogénures de (.omega.- aminoalkylamino)alkyle, leur conversion en phosphothioates de S-.omega.-(.omega.-aminoalkylamino)alkyle et la purification des produits cristallins de la réaction. Le procédé de fabrication d~halogénures de (.omega.-aminoalkylamino)alkyle comprend la mise en contact d~un alcool approprié avec un agent bromant en présence d~un solvant sulfoné dans des conditions de température et de pression adaptées à la formation d~un sel sans précipitation prématurée subséquente. Le procédé est particulièrement utile pour la conversion d~alcool (.omega.-aminoalkylamino)éthylique en amifostine.
Albermarle Corporation
Macrae & Co.
LandOfFree
Process for the preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1830763