Recombinant constructs and their use in reducing gene...

Details Recombinant constructs and their use in reducing gene... Recombinant constructs and their use in reducing gene...

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01)

Patent

CA 2408326

Recombinant constructs useful for reducing the expression of endogenous mRNA and any substantially similar endogenous mRNA are disclosed. In particular, a recombinant construct comprising, inter alia, a suitable nucleic acid sequence and its reverse complement can be used to alter the expression of any homologous, endogenous RNA (i.e., the target RNA) which is in proximity to this suitable nucleic acid sequence.

L'invention concerne des constructions recombinées utiles pour réduire l'expression d'ARNm endogène et de n'importe quel ARNm endogène sensiblement similaire. En particulier, une construction recombinée comprenant, inter allia, une séquence nucléotidique appropriée et son complément inverse peut être utilisée afin de modifier l'expression de n'importe quel ARN homologue endogène (c'est-à-dire, l'ARN cible) lequel se trouve à proximité de cette séquence nucléotidique appropriée.

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