Method for preparing pancreatic beta cells starting from...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/071 (2010.01) A61K 35/39 (2006.01) A61P 3/10 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2673944

The present invention relates to a method for preparing pancreatic islet cells, and preferably pancreatic beta cells starting from progenitor cells obtained from the pancreas of an adult mammal. The invention also provides a method for isolating progenitor cells, and preferably beta cell progenitors, from the pancreas of an adult mammal. Other aspects of the invention comprise the pancreatic islet (beta) cells and the progenitor cells that can be obtained with the present invention and their use, e.g. in diagnostic, therapeutic or research applications.

L'invention concerne un procédé qui permet de préparer des cellules d'îlot de Langerhans, et de préférence des cellules bêta pancréatiques, à partir de cellules progénitrices obtenues du pancréas d'un mammifère adulte. L'invention se rapporte aussi à un procédé qui permet d'isoler des cellules progénitrices, et de préférence des cellules progénitrices de cellules bêta, du pancréas d'un mammifère adulte. Dans d'autres aspects, l'invention porte sur les cellules (bêta) d'îlot de Langerhans et les cellules progénitrices qui peuvent être obtenues selon le procédé précité, et sur leur utilisation, p.ex. dans le diagnostic, la thérapeutique ou les applications de recherche.

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