Methods of modulating muscle contraction

Details Methods of modulating muscle contraction Methods of modulating muscle contraction

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2241389

Methods of modulating calcium independent smooth muscle contraction, and of modulating cardiac muscle contraction, by the administration of a PAK modulating agent are described. A method of treating a subject having a state characterized by smooth muscle contraction, (e.g., hypertension, asthma, irritable bowel syndrome, incontinence and menstrual cramps) or cardiac contractile dysfunction (e.g., heart failure and myocardial stunning) is also described. The method involves the administration, to a subject, of a therapeutically effective amount of a PAK modulating agent, e.g., a PAK inhibitor or stimulator. Assays, e.g., screening tests, to identify PAK modulating agents or agents that modulate muscle contraction are also provided.

Description de méthodes de modulation de la contraction des muscles lisses indépendante du calcium et de modulation de la contraction du muscle cardiaque par l'administration d'un agent modulant la PAK. Une méthode est également décrite pour traiter un sujet dont des muscles lisses sont contractés (p. ex., dans le cas de l'hypertension, de l'asthme, du côlon irritable, de l'incontinence et des crampes menstruelles) ou souffrant d'une dysfonction des contractions du muscle cardiaque (p. ex., dans le cas de l'insuffisance cardiaque et de la sidération myocardique). La méthode consiste à administrer à un sujet une dose thérapeutique d'un agent modulant la PAK, p. ex., un inhibiteur ou un stimulant de la PAK. Des dosages, p. ex., des tests de dépistage, servant à détecter les agents modulant la PAK ou les agents modulant la contraction musculaire sont aussi fournis.

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