C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/695 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2156919
New heterocyclic derivatives of formula (I) wherein R1 is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituent(s), R2 is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituents(s), R3 is hydrogen or acyl, R4 is hydrogen, lower alkyl, cyclo(lower)alkyl, cyclo(lower)alkyl-(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl ar(lower)alkyl which may have suitable substituent(s) ar(lower)alkenyl, bridged tricyclicalkyl, heterocyclic group which may have suitable substituent(s), acyl, or a group of formula (b) (in which A is lower alkylene), and R5 is hydrogen or lower alkyl, and a pharmaceutically acceptable salt thereof which are useful as interleukin-1 and tumor necrosis inhibitors.
Kawai Yoshio
Oku Teruo
Tanaka Hirokazu
Yamazaki Hitoshi
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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