C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/245 (2006.01) C07C 251/52 (2006.01) C07C 259/06 (2006.01) C07C 259/08 (2006.01) C07K 4/04 (2006.01) C07K 5/037 (2006.01) C07K 5/083 (2006.01) C07K 14/195 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2431997
The present invention relates to peptides having eubacterial b protein-binding properties and the surface of b protein with which said peptides and other proteins interact. The invention provides in vitro and in vivo assays for identifying compounds that modulate the interaction between b protein and proteins that interact therewith, and a method of controlling eubacterial infestation by modulating this interaction. The disclosed peptides can be used as templates for the design or selection of compounds that modulate the foregoing interaction.
L'invention concerne des peptides possédant des propriétés de fixation à des .beta.-protéines eubactériennes, ainsi que la surface de cette .beta.-protéine avec laquelle lesdits peptides et d'autres protéines exercent une interaction. Elle concerne des méthodes d'identification in vitro et in vivo de composés modulant l'interaction entre la .beta.-protéine et d'autres protéines, et un procédé de lutte contre l'infection eubactérienne par l'intermédiaire de la modulation de cette interaction. On peut utiliser ces peptides en tant que gabarits de conception ou de sélection de composés modulant cette interaction.
Dalrymple Brian Paul
Jennings Philip Anthony
Kemp Gregory William
Kongsuwan Kritaya
Wijffels Gene Louise
Commonwealth Scientific And Industrial Research Organisation
Goudreau Gage Dubuc
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