Diaryl compounds and uses thereof

Details Diaryl compounds and uses thereof Diaryl compounds and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 207/48 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/454 (2006.01) A61K 31/5375 (2006.01) A61P 25/00 (2006.01) C07D 211/14 (2006.01) C07D 211/48 (2006.01) C07D 213/71 (2006.01) C07D 265/30 (2006.01) C07D 307/22 (2006.01) C07D 309/14 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2727573

The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X7 are as defined here-in The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid receptors (KORs). Specifically, the compounds are selective antagonists of KORs and are highly selective to KORs relative to mu and delta opioid receptors.

Cette invention concerne des dérivés d'un composé de formule (I), dans laquelle R1 à R7 et and X1 à X7 sont tels que définis dans la description. Elle concerne également l'utilisation de ces dérivés pour le traitement de maladies, d'états et/ou de troubles médiés par les récepteurs opioïdes kappa (KOR). Plus particulièrement, ces composés sont des antagonistes sélectifs des KOR, et sont hautement sélectifs des KOR par rapport aux récepteurs opioïdes mu et delta.

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