A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/047 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2683548
The present invention relates to methods to modulate the assembly, folding, accumulation, rate of aggregation, oligomerization or clearance of proteins or fragments comprising PoIyQ, by using compositions comprising cyclohexanehexol derivatives. More specifically, the invention provides a medicament comprising cyclohexanehexol derivatives of formula III or formula IV, more particularly a scyllo-inositol compound, analog or derivative thereof, useful in the treatment of polyglutamine diseases, such as Huntington' s disease and related neurodegenerative disorders including dentatorubral pallidoluysian atrophy, spinal and bulbar muscular atrophy and spinocerebellar ataxia type 1, 2, 3, 6, 7 and 17.
La présente invention concerne des méthodes permettant de moduler l'assemblage, le pliage, l'accumulation, le taux d'agrégation, l'oligomérisation ou la clairance de protéines ou de fragments comprenant des polyglutamines (PolyQ), au moyen de compositions qui contiennent des dérivés de cyclohexanehexol. Plus spécifiquement, l'invention a pour objet un médicament comprenant des dérivés de cyclohexanehexol de formule III ou de formule IV, plus spécifiquement un composé de scyllo-inositol, un analogue ou un dérivé de ce composé, utilisés dans le traitement de maladies à répétition des polyglutamines, telles que la maladie de Huntington et des troubles neurodégénératifs associés qui englobent l'atrophie dentatorubro-pallidoluysienne, l'atrophie musculaire spinale et bulbaire et l'ataxie spinocérébelleuse de type 1, 2, 3, 6, 7 et 17.
Mclaurin Joanne
Mccarthy Tetrault Llp
Mclaurin Joanne
LandOfFree
Use of cyclohexanehexol derivatives for the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of cyclohexanehexol derivatives for the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of cyclohexanehexol derivatives for the treatment of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1832512