C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/24 (2006.01) A61K 39/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2251680
The invention relates to peptides consisting of 16 to 55 amino acid residues, said peptides comprising at least one of the amino acid sequences LVCYYTSWS (SEQ ID NO:60), FLCTHIIYS (SEQ ID NO:61), IIYSFANIS (SEQ ID NO:62), LKTLLSVGG (SEQ ID NO:63), FIKSVPPFL (SEQ ID NO:64), FDGLDLAWL (SEQ ID NO:65), LYPGRRDKQ (SEQ ID NO:66), YDIAKISQH (SEQ ID NO:67), LDFISIMTY (SEQ ID NO:68), FISIMTYDF (SEQ ID NO:69), FRGQEDASP (SEQ ID NO:70), YAVGYMLRL (SEQ ID NO:71), MLRLGAPAS (SEQ ID NO:72), LAYYEICDF (SEQ ID NO:73), LRGATVHRT (SEQ ID NO:74), YLKDRQLAG (SEQ ID NO:75), LAGAMVWAL (SEQ ID NO:76), VWALDLDDF (SEQ ID NO:77) or LDLDDFQGS (SEQ ID NO:78). The peptides can be used in the treatment of T-cell mediated destruction of articular cartilage. Administration of pharmaceutical compositions based on these peptides can be used to induce systemic immunological tolerance to the autoantigens under attack of the autoreactive T- cells.
L'invention se rapporte à des peptides comprenant 16 à 55 restes d'acides aminés et au moins une des séquences d'acides aminés suivantes: LVCYYTSWS (NO ID SEQ: 60), FLCTHIIYS (NO ID SEQ: 61), IIYSFANIS (NO ID SEQ: 62), LKTLLSVGG (NO ID SEQ: 63), FIKSVPPFL (NO ID SEQ: 64), FDGLDLAWL (NO ID SEQ: 65), LYPGRRDKQ (NO ID SEQ: 66), YDIAKISQH (NO ID SEQ: 67), LDFISIMTY (NO ID SEQ: 68), FISIMTYDF (NO ID SEQ: 69), FRGQEDASP (NO ID SEQ: 70), YAVGYMLRL (NO ID SEQ: 71), MLRLGAPAS (NO ID SEQ: 72), LAYYEICDF (NO ID SEQ: 73), LRGATVHRT (NO ID SEQ: 74), YLKDRQLAG (NO ID SEQ: 75), LAGAMVWAL (NO ID SEQ: 76), VWALDLDDF (NO ID SEQ: 77) ou LDLDDFQGS (NO ID SEQ: 78). Ces peptides peuvent être utilisés dans le traitement de la destruction du cartilage articulaire induite par les lymphocytes T. Des compositions pharmaceutiques constituées de ces peptides peuvent être administrées afin d'induire une tolérance immunologique systémique aux auto-antigènes lors de l'attaque des lymphocytes T autoréactifs.
Boots Anna Maria Helena
Verheijden Gijsbertus Franciscus Maria
Akzo Nobel Nv
Fetherstonhaugh & Co.
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