Fibrinogen binding peptides

Details Fibrinogen binding peptides Fibrinogen binding peptides

C - Chemistry, Metallurgy

07

K

C07K 5/107 (2006.01) C07K 1/22 (2006.01) C07K 4/00 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C07K 14/75 (2006.01)

Patent

CA 2196368

Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Phe-Leu-Leu-Val or Leu-Leu-Val-Pro sequence. The preferred peptide is a 6-mer having the sequence Phe-Leu-Leu-Val-Pro-Leu. A method of using these peptides in an affinity chromatography process to purify fibrinogen is described.

La divulgation a trait à des peptides qui lient la fibrinogène. Ces peptides renferment des domaines libres liant la fibrinogène dont la séquence est Phe-Leu-Leu-Val ou Leu-Leu-Val-Pro. Le peptide préférable comporte 6 acides aminés sont la séquence est Phe-Leu-Leu-Val-Pro-Leu. On décrit une méthode d'utilisation de ces peptides dans un procédé de chromatographie d'affinité destiné à purifier la fibrinogène.

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