Methods for identifying multiple primary targets of a drug

Details Methods for identifying multiple primary targets of a drug Methods for identifying multiple primary targets of a drug

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 1/26 (2006.01) G06F 19/00 (2006.01) G06M 3/00 (2006.01)

Patent

CA 2344267

This invention relates to methods and systems for characterizing the actions of drugs in cells. In particular, the invention provides methods for identifying multiple primary targets through which a drug, drug candidate, or other compound of interest acts on a cell. Thus, the invention also relates to methods for drug development based on the disclosed methods for identifying multiple primary targets of a drug. The methods of the invention involve: (i) measuring responses of cellular constituents to graded exposures of the cell to a drug of interest; (ii) identifying an "inflection concentration" of the drug for each cellular constituent measured; and (iii) identifying "expression sets" of cellular constituents from the distribution of the inflection drug concentrations. Each expression set corresponds to a particular primary target of the drug. The invention also provides computer systems which identify multiple targets of a drug by executing the disclosed methods.

L'invention concerne des méthodes et des systèmes servant à caractériser l'effet de médicaments dans des cellules. Cette invention porte notamment sur des méthodes d'identification de plusieurs cibles primaires par le biais desquelles un médicament, un médicament candidat, ou un autre composé d'intérêt agit sur une cellule. Ainsi, ladite invention a également trait aux méthodes de mise au point de médicaments fondées sur lesdites méthodes d'identification de plusieurs cibles primaires d'un médicament. Les méthodes de cette invention consistent à: (i) mesurer les réactions de constituants cellulaires à des expositions graduées de la cellule à un médicament d'intérêt, (ii) identifier une <=concentration d'inflexion>= du médicament pour chaque constituant cellulaire mesuré, et (iii) identifier des <=séries d'expression>= de constituants cellulaires à partir de la distribution des concentrations d'inflexion du médicament. Chaque série d'expression correspond à une cible primaire particulière du médicament. Cette invention concerne également des systèmes informatiques qui identifient plusieurs cibles d'un médicament en exécutant les méthodes divulguées.

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