Mutant dna encoding protein phosphatase 1 g-subunit

Details Mutant dna encoding protein phosphatase 1 g-subunit Mutant dna encoding protein phosphatase 1 g-subunit

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2157807

A DNA isolate is disclosed having a DNA sequence or comprising a fragment of the sequence encoding the protein phosphatase type 1 (PP1) G-subunit which sequence contains a mutation of G to T in the first position of codon 905 such that aspartic acid905 in the expressed PP1 G-subunit is substituted by tyrosine or which fragment spans the mutation. The isolate is useful in the diagnosis of predisposition to insulin resistance or reduced insulin-stimulated non-oxidative glucose metabolism in a subject.

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