Novel nucleosides having bicyclic sugar moiety

Details Novel nucleosides having bicyclic sugar moiety Novel nucleosides having bicyclic sugar moiety

A - Human Necessities

01

N

A01N 43/04 (2006.01) C07G 3/00 (2006.01) C07H 1/00 (2006.01) C07H 19/00 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2333380

Conformationally restricted 2',4'-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2' and C4' of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients. Oligonucleotides composed of these novel nucleosides are useful for oligonucleotide therapeutic and diagnostic compounds.

On décrit des analogues de nucléosides 2',4'-pontés à conformation limitée. Ces composés peuvent être préparés par cyclisation en C2' et C4' des nucléosides au moyen d'un lieur ou d'une molécule de liaison. Ces nouveaux nucléosides présentent un fronçage sucre fermé et peuvent être utiles comme ingrédients pharmaceutiques. Les oligonucléotides constitués desdits nouveaux nucléosides peuvent entrer dans des composés oligonucléotidiques destinés à un usage diagnostique ou thérapeutique.

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