Diagnostic and therapeutic methods using the h37 tumor...

Details Diagnostic and therapeutic methods using the h37 tumor... Diagnostic and therapeutic methods using the h37 tumor...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2405551

The present invention relates to the identification of the H37 tumor suppressor gene and methods of diagnosing and treating a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer. Diagnosis is accomplished examining or monitoring cells for perturbations in H37 expression or function. Treatment is accomplished by inserting a host cell compatible H37 expression vector or an effective amount of H37 protein into a cell or cells in need of treatment.

La présente invention concerne l'identification du gène suppresseur de tumeur H37 ainsi que des procédés permettant de diagnostiquer et de traiter une maladie ou un trouble caractérisé par une prolifération cellulaire anomale, tel qu'une tumeur ou un cancer. Un diagnostic s'effectue en examinant ou contrôlant des cellules en ce qui concerne des perturbations dans l'expression ou la fonction de H37. Le traitement s'effectue par insertion d'un vecteur d'expression H37 ou d'une quantité efficace de protéine H37 compatible avec une cellule hôte dans au moins une cellule nécessitant un traitement.

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