The use of certain affinity nmda antagonists as antidepressants

Details The use of certain affinity nmda antagonists as antidepressants The use of certain affinity nmda antagonists as antidepressants

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61K 31/00 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2359568

The invention relates to the use of certain low affinity NMDA antagonists as antidepressant agents. Preferred compounds include compounds of formula (I) wherein R1 is pyridyl, phenyl or 4-fluorophenyl; R2 is phenyl or 4- fluorophenyl; R3 is hydrogen, C1-6 alkyl or methoxycarbonyl; R4 is hydrogen or methyl; and R5 is hydrogen or COCH2NH2, and pharmaceutically acceptable salts thereof.

L'invention concerne l'utilisation de certains antagonistes du NMDA (N-méthyl-D-aspartate), de faible affinité, en tant qu'agents antidépresseurs. Des composés préférés comprennent des composés correspondant à la formule (I) dans laquelle R?1¿ représente pyridyle, phényle ou 4-fluorophényle; R?2¿ représente phényle ou 4-fluorophényle; R?3¿ représente hydrogène, alkyle C¿1-6? ou méthoxycarbonyle; R?4¿ représente hydrogène ou méthyle, et R?5¿ représente hydrogène ou COCH¿2?NH¿2?. L'invention concerne également des sels de ces composés, acceptables sur le plan pharmacologique.

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