Method and antisense compound for potentiating anti-cancer...

Details Method and antisense compound for potentiating anti-cancer... Method and antisense compound for potentiating anti-cancer...

A - Human Necessities

61

K

A61K 31/7125 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 31/675 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2544923

A method and compound for enhancing the lethality of an anti-cancer therapy, such as radiation, chemotherapy, or TRAIL protein, are disclosed. The compound is composed of morpholino subunits joined by phosphorodiamidate linkages, and has a targeting sequence that is complementary to an AUG start, IRES, or splice-donor region of the transcript for human X-linked inhibitor of apoptosis protein (XIAP). The method includes exposing cancer cells to the compound.

L'invention concerne une méthode et un composé permettant d'améliorer la létalité d'une thérapie anticancéreuse, telle qu'une thérapie reposant sur des rayonnements, une chimiothérapie ou une protéine TRAIL. Ledit composé est constitué de sous-unités de morpholine liées par des liaisons de phosphorodiamidate et il présente une séquence de ciblage qui est complémentaire à un départ AUG, IRES ou une région donatrice d'épissure du produit de la transcription pour inhibiteur humain lié à X d'une protéine d'apoptose (XIAP). Cette méthode consiste à exposer des cellules cancéreuses au composé.

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