Novel therapeutic targets in cancer

Details Novel therapeutic targets in cancer Novel therapeutic targets in cancer

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 2/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 17/00 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) C40B 40/00 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2564131

The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer ~associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

La présente invention a trait à de nouvelles séquences destinées à être utilisées dans la détection, le diagnostic et le traitement des cancers, notamment des lymphomes. L'invention a trait à des séquences polynucléotidiques dont l'expression est associée au cancer. La présente invention a trait à des polypeptides associés au cancer qui sont présents à la surface des cellules et de nouveaux cibles thérapeutiques contre le cancer. La présente invention a également trait à des compositions diagnostiques et à des procédés pour la détection du cancer. La présente invention a trait en outre à des anticorps monoclonaux et polyclonaux spécifiques pour les polypeptides associés au cancer. Enfin, l'invention a trait à des outils diagnostiques et des compositions thérapeutiques et des procédés pour le dépistage, la prévention et le traitement du cancer.

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