Ph modulated films for delivery of actives

Details Ph modulated films for delivery of actives Ph modulated films for delivery of actives

A - Human Necessities

61

K

A61K 9/70 (2006.01)

Patent

CA 2631431

The invention relates to pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.

La présente invention concerne des films au pH régulé et leurs procédés de préparation. Les compositions des films renferment au moins un composant possédant un pH non neutre lorsqu~il est associé avec de l~eau ; et un système de polymère au pH régulé sélectionné en vue de réduire ou d~empêcher la synérèse lorsqu~il est associé avec un composant non neutre dans un milieu aqueux. Les films présentent une hétérogénéité uniforme non auto-agglomérante. Idéalement, les films se dissolvent dans l~eau et peuvent se former à l~aide d~un procédé de séchage, un procédé d~extrusion ou d~autres procédés régulés qui maintiennent l~uniformité requise du film.

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