A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/43 (2006.01) A61K 9/50 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2480824
The invention concerns liquid pharmaceutical formulations, for oral delivery, with modified release of amoxicillin and consisting of suspensions of coated particles of amoxicillin (microcapsules). The microcapsules constituting the dispersed phase of the suspension are designed, according to the invention, to enable modified release of amoxicillin, in accordance with a profile which remains unaltered during the shelf life of the liquid suspension. Therefor, the invention consists in selecting a coating composition specific to the microcapsules consisting of at least four components enabling preservation of said microcapsules in water without altering their properties of modified release of amoxicillin, said liquid phase being furthermore saturated with amoxicillin.
L'invention concerne des formulations pharmaceutiques liquides, administrables oralement, à libération modifiée d'amoxicilline et constituées par des suspensions de particules d'amoxicilline enrobées (microcapsules). Les microcapsules constituant la phase dispersée de la suspension sont conçues, conformément à l'invention, pour permettre la libération modifiée de l'amoxicilline, selon un profil n'évoluant pas au cours du stockage de la suspension liquide. Pour ce faire, les inventeurs proposent de sélectionner une composition d'enrobage spécifique pour les microcapsules constituée d'au moins quatre composants permettant de conserver ces microcapsules dans l'eau sans modifier leurs propriétés de libération modifiée de l'amoxicilline, cette phase liquide étant par ailleurs saturée en amoxicilline.
Castan Catherine
Guimberteau Florence
Meyrueix Remi
Flamel Technologies
Robic
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